Wednesday 1:00 PM- Thursday 12:00 PM
Machine Learning on Big Data

Instructor: Kao-Tai Tsai

Course Description
Technical advancement in big data generation necessitates the data analytical skills to extract important tactical information more critical than ever. By taking advantages of advanced computing technologies and modern statistical research, machine learning has becoming one of the most sought-after capabilities in big data analysis to meet such challenges. Machine learning methodologies have broad applications and have been implemented in discovering precision medicines, advancing scientific research, and helping commerce in market segmentation and targeted product development.

What will be discussed:
o Part 1: general philology of data analysis according to Professors Tukey and Huber, and data quality related to big data.
o Part 2: exploring data structures and distributions using graphical tools and recursive partitioning methodologies.
o Part 3: supervised regression and classification methods including lasso, elastic-net, support vector machine, etc.
o Part 4: non-supervised methods including clustering, principle component analysis, corresponding analysis, etc.
o Part 5: case studies with genomics data and commercial data.

Who should attend: statisticians and data scientists in all industries with data analysis experience and knowledge of programming language such as R, SAS, or Python. (Note: course examples of data analyses will be illustrated using R.)



Wednesday 1:00 PM- Thursday 12:00 PM
Adaptive Clinical Trial Designs: Early and Late Phase Developments

Instructor: Pantelis Vlachos

Course Description
The purpose of this short course is to first better familiarize attendees with the underlying statistical methods, then instruct you on designing related trials of greatest interest to you and your organization. Case studies of actual adaptive trials will both illustrate the use of the methodologies and serve as hands-on design examples.
We will cover Early Phase Dose Escalation Designs, Adaptive Dose Finding Methods, Multi-Arm Multi-Stage Designs and Sample Size Re-estimation with or without enrichment of particular subgroups.